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American Society of Hematology, Blood, 4(131), p. 450-461

DOI: 10.1182/blood-2017-08-799908

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HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency

Journal article published in 2017 by Shuping Zhang ORCID, Alejandra Macias-Garcia ORCID, Jason Velazquez, Elena Paltrinieri, Randal J. Kaufman, Jane Chen ORCID
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Key Points Erythroid eIF2αP and ATF4 are essential for iron-restricted erythropoiesis, and HRI-eIF2αP is responsible for microcytic hypochromic anemia. HRI activates integrated stress response and represses mTORC1 signaling in ID to mitigate ineffective erythropoiesis.