Published in
American Society of Hematology, Blood, 4(131), p. 450-461
DOI: 10.1182/blood-2017-08-799908
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HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency
Journal article published in 2017 by
Shuping Zhang 
,
Alejandra Macias-Garcia ,
Jason Velazquez,
Elena Paltrinieri,
Randal J. Kaufman,
Jane Chen
,
Alejandra Macias-Garcia ,
Jason Velazquez,
Elena Paltrinieri,
Randal J. Kaufman,
Jane Chen
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Abstract
Key Points Erythroid eIF2αP and ATF4 are essential for iron-restricted erythropoiesis, and HRI-eIF2αP is responsible for microcytic hypochromic anemia. HRI activates integrated stress response and represses mTORC1 signaling in ID to mitigate ineffective erythropoiesis.