Published in
American Society of Hematology, Blood, 20(131), p. 2235-2246
DOI: 10.1182/blood-2017-10-810630
Links
Tools
The tumor suppressive TGF-β/SMAD1/S1PR2 signaling axis is recurrently inactivated in diffuse large B-cell lymphoma
Journal article published in 2018 by
Anna Stelling,
Hind Hashwah,
Katrin Bertram,
Markus G. Manz 
,
Alexandar Tzankov,
Anne Müller
,
Alexandar Tzankov,
Anne Müller
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
Full text: Unavailable
Preprint: archiving forbidden
Published version:
archiving forbidden
Data provided by 
Abstract
Key Points The sphingosine-1-phosphate receptor 2 is a bona fide tumor suppressor and transcriptionally regulated by the TGF-β/TGF-βR2/SMAD1 axis. The aberrant loss of SMAD1 expression is very common in DLBCL and provides a proliferative advantage to B cells in vitro and in vivo.