Published in
American Association for the Advancement of Science, Science Translational Medicine, 391(9), 2017
DOI: 10.1126/scitranslmed.aal4682
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The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation
Journal article published in 2017 by
David P. Kodack 
,
Vasileios Askoxylakis ,
Gino B. Ferraro,
Qing Sheng ,
Mark Badeaux,
Shom Goel ,
Xiaolong Qi,
Ram Shankaraiah ,
Z. Alexander Cao,
Rakesh R. Ramjiawan ,
Divya Bezwada,
Bhushankumar Patel,
Yongchul Song ,
Carlotta Costa,
Kamila Naxerova
and other authors.
,
Vasileios Askoxylakis ,
Gino B. Ferraro,
Qing Sheng ,
Mark Badeaux,
Shom Goel ,
Xiaolong Qi,
Ram Shankaraiah ,
Z. Alexander Cao,
Rakesh R. Ramjiawan ,
Divya Bezwada,
Bhushankumar Patel,
Yongchul Song ,
Carlotta Costa,
Kamila Naxerova
and other authors.
This paper was not found in any repository, but could be made available legally by the author.
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Abstract
The brain microenvironment triggers HER3-dependent de novo resistance to therapies targeting PI3K or HER2 in HER2-positive and/or PIK3CA -mutant breast cancer cells.