Published in
American Society of Hematology, Blood, p. blood-2018-05-849059
DOI: 10.1182/blood-2018-05-849059
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Prognostic impact of t(16;21)(p11;q22) and t(16;21)(q24;q22) in pediatric AML: a retrospective study by the I-BFM Study Group
Journal article published in 2018 by
Sanne Noort,
Martin Zimmermann,
Dirk Reinhardt,
Wendy Cuccuini,
Martina Pigazzi,
Jenny Smith,
Rhonda E. Ries,
Todd A. Alonzo,
Betsy Hirsch,
Daisuke Tomizawa 
,
Franco Locatelli,
Tanja A. Gruber,
Susana Raimondi,
Edwin Sonneveld,
Daniel K. Cheuk
and other authors.
,
Franco Locatelli,
Tanja A. Gruber,
Susana Raimondi,
Edwin Sonneveld,
Daniel K. Cheuk
and other authors.
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Abstract
Key Points t(16;21) translocations in AML comprise t(16;21)(p11;q22) (FUS-ERG) as well as t(16;21)(q24;q22) (RUNX1-CBFA2T3). Survival in pediatric AML with FUS-ERG is poor, whereas survival in RUNX1-CBFA2T3 is similar to other core-binding factor leukemias.