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American Society for Microbiology, Journal of Clinical Microbiology, 9(49), p. 3343-3345, 2011

DOI: 10.1128/jcm.00563-11

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Evaluation of three automated systems for susceptibility testing of enterobacteria containing qnrB, qnrS, and/or aac(6')-Ib-cr.

Journal article published in 2011 by Jorge Calvo, María Eliecer Cano, Cristina Pitart, Francesc Marco, José Manuel Rodríguez-Martínez, Alvaro Pascual ORCID, Luis Martínez-Martínez
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

quinolones and aminoglycosides against 68 enterobacteria containing qnrB, qnrS, and/or aac(6)-Ib-cr was evaluated using reference microdilution. Overall, one very major error (0.09%), 6 major errors (0.52%), and 45 minor errors (3.89%) were noted. Previous reports indicate that automated systems for suscep-tibility testing are reliable in detecting quinolone-resistant en-terobacteria (4, 7, 9, 12), but there is very limited information on the accuracy of these systems with organisms expressing plasmid-mediated quinolone resistance (PMQR) mechanisms. PMQR genes determine the low level of resistance to quino-lones and may favor or complement the selection of additional mechanisms (5, 6, 10). They code for Qnr proteins, the acetyl-transferase Aac(6)-Ib-cr, or the efflux systems QepA and OqxAB. Aac(6)-Ib-cr also confers resistance to tobramycin and amikacin. Detection of strains harboring PMQR mechanisms usually