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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(55), p. 4422-4423, 2011

DOI: 10.1128/aac.00564-11

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Coresistance to Isoniazid and Ethionamide Maps to Mycothiol Biosynthetic Genes in Mycobacterium bovis

Journal article published in 2011 by Catherine Vilcheze, Yossef Av-Gay ORCID, S. Whitney Barnes, Michelle H. Larsen, John R. Walker, Richard J. Glynne, William R. Jacobs ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT A search to identify new mechanisms of isoniazid resistance in Mycobacterium bovis led to the isolation of mutants defective in mycothiol biosynthesis due to mutations in genes coding for the glycosyltransferase ( mshA ) or the cysteine ligase ( mshC ). These mutants showed low-level resistance to isoniazid but were highly resistant to ethionamide. This study further illustrates that mutations in mycothiol biosynthesis genes may contribute to isoniazid or ethionamide resistance across mycobacterial species.