Published in

American Society for Microbiology, Journal of Bacteriology, 2(186), p. 267-269, 2004

DOI: 10.1128/jb.186.2.267-269.2004

Links

Tools

Export citation

Search in Google Scholar

Digging with Experimental Pick and Computational Shovel: a New Addition to the Histidine Kinase Superfamily

Journal article published in 2003 by Igor B. Zhulin ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Orange circle
Published version: archiving restricted
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

Experimental microbiology in the postgenomic era has sur- vived the first wave of uncertainty: a perspective of being re- placed by in silico microbiology. Although it is clear now that experimental science is irreplaceable, we are facing yet another wave: the frustration of having a half million microbial genes in databases but lacking simple ways of getting biologically rele- vant information. Therefore, it is reassuring to see some clear water between the waves: examples of experimental research that takes advantage of a comparative genomic approach one step at a time. The paper by Karniol and Vierstra in this issue (10) describing a new family of histidine kinases shows how the use of simple bioinformatics tools by microbiologists can (i) identify new targets for experimental work and (ii) provide important feedback for improving these tools.