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Nature Research, Nature Neuroscience, 11(12), p. 1367-1369, 2009

DOI: 10.1038/nn.2403

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Transitions in infant learning are modulated by dopamine in the amygdala

Journal article published in 2009 by Gordon A. Barr, Stephanie Moriceau ORCID, Kiseko Shionoya, Kyle Muzny, Puhong Gao, Shaoning Wang, Regina M. Sullivan
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Behavioral transitions characterize development. Young infant rats paradoxically prefer odors paired with shock but older pups learn aversions. This transition is amygdala- and corticosterone-dependent. Microarray and microdialysis studies here showed downregulated dopaminergic presynaptic function in the amygdala with preference learning. Corticosterone–injected 8-day-old pups and untreated 12-day-old pups learn aversions and had dopaminergic upregulation in the amygdala. Dopamine injection into the amygdala changed preferences to aversions; dopamine antagonism reinstated preference learning.