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MDPI, Marine Drugs, 12(10), p. 209-222, 2012

DOI: 10.3390/md10010209

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Bioactive Hydroperoxyl Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum

Journal article published in 2012 by Mohamed-Elamir F. Hegazy ORCID, Hegazy Me, Gamal Eldeen Am, Amira M. Gamal Eldeen, Amira M. Gamal Eldeen ORCID, Shahat Aa, Abdelaaty A. Shahat, Fathy F. Abdel-Latif, Abdel Latif Ff, Tarik A. Mohamed, Bruce R. Whittlesey, Mohamed Ta, Whittlesey Br, Paul W. Paré ORCID, Paré Pw
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P450 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.