Published in
American Society of Hematology, Blood Advances, 23(1), p. 2046-2057, 2017
DOI: 10.1182/bloodadvances.2017006148
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Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells
Journal article published in 2017 by
Mia Eriksson,
Pablo Peña-Martínez 
,
Ramprasad Ramakrishnan,
Marion Chapellier,
Carl Högberg,
Gabriella Glowacki,
Christina Orsmark-Pietras,
Talía Velasco-Hernández ,
Vladimir Lj Lazarević,
Gunnar Juliusson,
Jörg Cammenga,
James C. Mulloy,
Johan Richter,
Thoas Fioretos,
Benjamin L. Ebert
and other authors.
,
Ramprasad Ramakrishnan,
Marion Chapellier,
Carl Högberg,
Gabriella Glowacki,
Christina Orsmark-Pietras,
Talía Velasco-Hernández ,
Vladimir Lj Lazarević,
Gunnar Juliusson,
Jörg Cammenga,
James C. Mulloy,
Johan Richter,
Thoas Fioretos,
Benjamin L. Ebert
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points TLR1 is upregulated on primitive AML cells. Agonistic targeting of TLR1/TLR2 induces apoptosis and differentiation of primitive AML cells in vivo.