Published in
American Society of Hematology, Blood, 16(129), p. 2291-2302, 2017
DOI: 10.1182/blood-2016-11-749879
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Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development
Journal article published in 2017 by
Saravanan Subramaniam 
,
Kerstin Jurk ,
Lukas Hobohm ,
Sven Jäckel,
Mona Saffarzadeh,
Kathrin Schwierczek ,
Philip Wenzel ,
Florian Langer,
Christoph Reinhardt ,
Wolfram Ruf
,
Kerstin Jurk ,
Lukas Hobohm ,
Sven Jäckel,
Mona Saffarzadeh,
Kathrin Schwierczek ,
Philip Wenzel ,
Florian Langer,
Christoph Reinhardt ,
Wolfram Ruf
This paper is made freely available by the publisher.
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Abstract
Key PointsMyeloid cell TF-dependent venous thrombosis is under control of PDI and the complement cascade. C5 deficiency reduces fibrin formation and leukocyte PS exposure with normal platelet deposition in flow-restricted vessels.