Published in
American Association for the Advancement of Science, Science Signaling, 481(10), 2017
DOI: 10.1126/scisignal.aai8904
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A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding
Journal article published in 2017 by
Jianmin Zuo 
,
Carrie R. Willcox ,
Fiyaz Mohammed,
Martin Davey ,
Stuart Hunter ,
Kabir Khan ,
Ayman Antoun ,
Poonam Katakia,
Joanne Croudace,
Charlotte Inman ,
Helen Parry,
David Briggs ,
Ram Malladi ,
Benjamin E. Willcox ,
Paul Moss
,
Carrie R. Willcox ,
Fiyaz Mohammed,
Martin Davey ,
Stuart Hunter ,
Kabir Khan ,
Ayman Antoun ,
Poonam Katakia,
Joanne Croudace,
Charlotte Inman ,
Helen Parry,
David Briggs ,
Ram Malladi ,
Benjamin E. Willcox ,
Paul Moss
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Abstract
A disease-associated variant of an activating ligand engages receptors so strongly that it impairs NK cell–mediated killing.