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Wiley, Cellular Microbiology, 5(16), p. 701-708, 2014

DOI: 10.1111/cmi.12270

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Evidence of promiscuous endothelial binding by P lasmodium falciparum ‐infected erythrocytes

Journal article published in 2014 by Claudia Esser, Anna Bachmann, Daniela Kuhn, Kathrin Schuldt, Birgit Förster, Meike Thiel, Jürgen May, Friedrich Koch‐Nolte ORCID, María Yáñez‐Mó, Francisco Sánchez‐Madrid, Alfred H. Schinkel, Sirpa Jalkanen, Alister G. Craig, Iris Bruchhaus, Rolf D. Horstmann
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The adhesion of infected red blood cells (iRBCs) to human endothelium is considered a key event in the pathogenesis of cerebral malaria and other life-threatening complications caused by the most prevalent malaria parasite Plasmodium falciparum. In the past thirty years, fourteen endothelial receptors for iRBCs have been identified. Exposing ten additional surface proteins of endothelial cells to a mixture of P. falciparum isolates from three Ghanaian malaria patients, we identified seven new iRBC receptors, all expressed in brain vessels. This finding strongly suggests that endothelial binding of P. falciparum iRBCs is promiscuous and may use a combination of endothelial surface moieties.