Published in
American Society of Hematology, Blood, 13(129), p. 1779-1790
DOI: 10.1182/blood-2016-06-721977
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Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells
Journal article published in 2017 by
Hiroyoshi Kunimoto,
Anna Sophia McKenney,
Cem Meydan 
,
Kaitlyn Shank,
Abbas Nazir,
Franck Rapaport ,
Benjamin Durham ,
Francine E. Garrett-Bakelman,
Elodie Pronier,
Alan H. Shih,
Ari Melnick,
Jayanta Chaudhuri,
Ross L. Levine
,
Kaitlyn Shank,
Abbas Nazir,
Franck Rapaport ,
Benjamin Durham ,
Francine E. Garrett-Bakelman,
Elodie Pronier,
Alan H. Shih,
Ari Melnick,
Jayanta Chaudhuri,
Ross L. Levine
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Abstract
Key Points Aid loss leads to altered differentiation, transcription, and methylation in specific genetic loci in hematopoietic stem/progenitor cells. Aid loss does not contribute to enhanced HSC self-renewal or cooperate with Flt3-ITD in myeloid leukemogenesis.