From a descriptive-functional paradigm, this study explores how universities contribute to the promotion of entrepreneurship and the growth of small and medium enterprises in Chile. This fact constitutes the first approximation to the phenomenon of installing a national network of business development centers driven by the Technical Cooperation Service (SERCOTEC, for its acronym in Spanish), a private law corporation and a body dependent on the Ministry of Economy, Development, and Tourism of Chile. The study uses a qualitative methodology of phenomenological order, and it concludes as of diverse experiences about the achievements evidenced by a group of sixteen business owners advised by these centers from different locations of Chile.