Published in
American Association for the Advancement of Science, Science Signaling, 495(10), 2017
DOI: 10.1126/scisignal.aam9931
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Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins
Journal article published in 2017 by
Katharine A. White 
,
Diego Garrido Ruiz ,
Zachary A. Szpiech ,
Nicolas B. Strauli ,
Ryan D. Hernandez,
Matthew P. Jacobson ,
Diane L. Barber
,
Diego Garrido Ruiz ,
Zachary A. Szpiech ,
Nicolas B. Strauli ,
Ryan D. Hernandez,
Matthew P. Jacobson ,
Diane L. Barber
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Abstract
High intracellular pH in cancer cells enables the oncogenic effects of Arg-to-His mutations in proteins.