Dissemin is shutting down on January 1st, 2025

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De Gruyter, Clinical Chemistry and Laboratory Medicine, 7(55), 2017

DOI: 10.1515/cclm-2016-0615

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Assessment of autoantibodies to interferon-ω in patients with autoimmune polyendocrine syndrome type 1: using a new immunoprecipitation assay

Journal article published in 2017 by Maria del Pilar Larosa, Rachel Mackenzie, Peter Burne, Silvia Garelli, Susi Barollo, Stefano Masiero ORCID, Beatrice Rubin, Shu Chen, Jadwiga Furmaniak, Corrado Betterle, Bernard Rees Smith
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Distributing this paper is prohibited by the publisher

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Abstract

AbstractBackground:Measurements of autoantibodies to interferon-ω (IFN-ω) in patients with autoimmune polyglandular syndrome type 1 (APS-1) were performed using a new immunoprecipitation assay (IPA) based onMethods:We have developed and validated a new IPA based onResults:Sixty-six (84.6%) of 78 APS-1 patients were positive for IFN-ω Ab usingConclusions:We have developed a novel, highly sensitive and specific assay for measurement of IFN-ω Ab. It provides a simple and convenient method for the assessment of patients with APS-1 and selecting patients suspected of having APS-1 for