Published in

Nature Research, Nature Reviews Genetics, 9(15), p. 577-584, 2014

DOI: 10.1038/nrg3785

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Recent advances in genomic DNA sequencing of microbial species from single cells

Journal article published in 2014 by Roger S. Lasken, Jeffrey S. McLean ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The vast majority of microbial species remain uncultivated and, until recently, about half of all known bacterial phyla were identified only from their 16S ribosomal RNA gene sequence. With the advent of single-cell sequencing, genomes of uncultivated species are rapidly filling in unsequenced branches of the microbial phylogenetic tree. The wealth of new insights gained from these previously inaccessible groups is providing a deeper understanding of their basic biology, taxonomy and evolution, as well as their diverse roles in environmental ecosystems and human health.