AbstractThe hydroxyl (OH) radical is the key oxidant in the global atmosphere as it controls the concentrations of toxic gases like carbon monoxide and climate relevant gases like methane. In some regions, oxidation by chlorine (Cl) radical is also important, and in the stratosphere both OH and Cl radicals impact ozone. An empirical method is presented to determine effective OH concentrations in the troposphere and lower stratosphere, based on CH₄, CH₃Cl, and SF₆ data from aircraft measurements (IAGOS-CARIBIC) and a ground-based station (NOAA). Tropospheric OH average values of 10.9 × 10⁵ (σ = 9.6 × 10⁵) molecules cm⁻³ and stratospheric OH average values of 1.1 × 10⁵ (σ = 0.8 × 10⁵) molecules cm⁻³ were derived over mean ages derived from SF₆. Using CH₄ led to higher OH estimates due to the temperature dependence of the CH₄ + OH reaction in the troposphere and due to the presence of Cl in the stratosphere. Exploiting the difference in effective OH calculated from CH₃Cl and CH₄ we determine the main altitude for tropospheric CH₄ oxidation to be 4.5 ~ 10.5 km and the average Cl radical concentration in the lower stratosphere to be 1.1 × 10⁴ (σ = 0.6 × 10⁴) molecules cm⁻³ (with a 35% measurement uncertainty). Furthermore, the data are used to examine the temporal trend in annual average stratospheric OH and Cl radical concentrations between 2010 and 2015. The year 2013 showed highest stratospheric OH and lowest Cl but no clear temporal trend was observed in the data in this period. These data serve as a baseline for future studies of stratospheric circulation changes.