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American Society of Hematology, Blood, p. blood-2018-01-828418

DOI: 10.1182/blood-2018-01-828418

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CK1α and IRF4 are essential and independent effectors of immunomodulatory drugs in primary effusion lymphoma

Journal article published in 2018 by Mark Manzano, Ajinkya Patil ORCID, Eva Gottwein
Distributing this paper is prohibited by the publisher
Distributing this paper is prohibited by the publisher

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Abstract

Key Points CK1α is essential for the survival of PEL cell lines, and its degradation mediates toxicity of IMiDs. Loss of IRF4 expression is a CK1α-, IKZF1-, and IKZF3-independent arm of IMiD toxicity in PEL cell lines.