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Karger Publishers, Caries Research, 1-2(52), p. 1-6, 2017

DOI: 10.1159/000479826

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Polymorphisms in Nonamelogenin Enamel Matrix Genes Are Associated with Dental Fluorosis

Journal article published in 2017 by Erika Calvano Küchler, C. D. Bruzamolin, Carolina Dea Bruzamolin, Marjorie Ayumi Omori, Omori, Marcelo C. Costa, Leonardo Santos Antunes, Giovana Daniela Pecharki, Paula Cristina Trevilatto ORCID, Alexandre Rezende Vieira ORCID, João Armando Brancher ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The aim of this study was to evaluate whether genetic polymorphisms in <i>AMELX</i>,<i> AMBN</i>,<i> ENAM</i>,<i> TFIP11</i>, and<i> TUFT1</i> genes are associated with dental fluorosis (DF). A total of 1,017 children from 2 Brazilian cohorts were evaluated. These populations lived in cities with fluoridation of public water supplies. DF was assessed in erupted permanent teeth using the modified Dean index. The polymorphisms rs946252, rs12640848, rs4694075, rs5997096, and rs4970957 were analyzed by real-time PCR from genomic DNA. Associations between DF, genotype, and allele distribution were evaluated using the &#x03C7;<sup>2</sup> test, with an alpha of 5%. The polymorphisms rs4694075, rs5997096, and rs4970957 in <i>AMBN</i>, <i>TFIP11</i>, and <i>TUFT1</i> were associated with DF (<i>p</i> < 0.05). In conclusion, enamel matrix genes are associated with DF.