Dissemin is shutting down on January 1st, 2025

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Karger Publishers, Caries Research, 1-2(52), p. 1-6, 2017

DOI: 10.1159/000479826

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Polymorphisms in Nonamelogenin Enamel Matrix Genes Are Associated with Dental Fluorosis

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO

Abstract

The aim of this study was to evaluate whether genetic polymorphisms in <i>AMELX</i>,<i> AMBN</i>,<i> ENAM</i>,<i> TFIP11</i>, and<i> TUFT1</i> genes are associated with dental fluorosis (DF). A total of 1,017 children from 2 Brazilian cohorts were evaluated. These populations lived in cities with fluoridation of public water supplies. DF was assessed in erupted permanent teeth using the modified Dean index. The polymorphisms rs946252, rs12640848, rs4694075, rs5997096, and rs4970957 were analyzed by real-time PCR from genomic DNA. Associations between DF, genotype, and allele distribution were evaluated using the &#x03C7;<sup>2</sup> test, with an alpha of 5%. The polymorphisms rs4694075, rs5997096, and rs4970957 in <i>AMBN</i>, <i>TFIP11</i>, and <i>TUFT1</i> were associated with DF (<i>p</i> < 0.05). In conclusion, enamel matrix genes are associated with DF.