AbstractIn this minireview, we summarize the recent development of liquid‐infused slippery surfaces (LISS) for biomedical applications. The selected topics are divided into two parts: the material designs and emerging strategies to fabricate slippery surface, and their applications with strong and direct relevance to biomedical areas including antibiofouling, antithrombosis, medical device coatings and surface enhanced/assisted detection. We also describe the most critical directions in need of development to adapt this new approach to biomedical use.