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American Society for Microbiology, Clinical and Vaccine Immunology, 3(14), p. 331-333, 2007

DOI: 10.1128/cvi.00351-06

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Recombinant Protein-Based Assays for Detection of Antibodies to Severe Acute Respiratory Syndrome Coronavirus Spike and Nucleocapsid Proteins

Journal article published in 2007 by Lia M. Haynes, Congrong Miao, Jennifer L. Harcourt, Joel M. Montgomery, Mai Quynh Le, Sergey A. Dryga, Kurt I. Kamrud, Bryan Rivers, Gregory J. Babcock, Jennifer Betts Oliver, James A. Comer, Mary Reynolds ORCID, Timothy M. Uyeki, Daniel Bausch, Thomas Ksiazek and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Recombinant severe acute respiratory syndrome (SARS) nucleocapsid and spike protein-based immunoglobulin G immunoassays were developed and evaluated. Our assays demonstrated high sensitivity and specificity to the SARS coronavirus in sera collected from patients as late as 2 years postonset of symptoms. These assays will be useful not only for routine SARS coronavirus diagnostics but also for epidemiological and antibody kinetic studies. Copyright © 2007, American Society for Microbiology. All Rights Reserved.