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Oxford University Press (OUP), Bioinformatics, 21(25), p. 2787-2794

DOI: 10.1093/bioinformatics/btp510

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A novel algorithm for detecting differentially regulated paths based on gene set enrichment analysis

Journal article published in 2009 by Andreas Keller, Christina Backes, Andreas Gerasch, Michael Kaufmann, Oliver Kohlbacher, Eckart Meese, Hans-Peter Lenhof,
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: Deregulated signaling cascades are known to play a crucial role in many pathogenic processes, among them are tumor initiation and progression. In the recent past, modern experimental techniques that allow for measuring the amount of mRNA transcripts of almost all known human genes in a tissue or even in a single cell have opened new avenues for studying the activity of the signaling cascades and for understanding the information flow in the networks.