Published in
Royal Society of Chemistry, RSC Advances, 49(8), p. 28189-28197, 2018
DOI: 10.1039/c8ra03145b
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Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Journal article published in 2018 by
Longguang Jiang 
,
Xu Zhang,
Yang Zhou,
Yayu Chen,
Zhipu Luo,
Jinyu Li,
Cai Yuan,
Mingdong Huang
,
Xu Zhang,
Yang Zhou,
Yayu Chen,
Zhipu Luo,
Jinyu Li,
Cai Yuan,
Mingdong Huang
This paper is made freely available by the publisher.
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Abstract
BrBA binds to the S1 pocket of urokinase with Br facing the base of the pocket by halogen bonds, while iodine of IBA binds to the S1 in the opposite way.