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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 11(49), p. 4778-4780, 2005

DOI: 10.1128/aac.49.11.4778-4780.2005

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Differential Antibiotic Susceptibilities of Starved Mycobacterium tuberculosis Isolates

Journal article published in 2005 by Zhifang Xie, Noman Siddiqi, Eric J. Rubin ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT We compared the efficacies of 17 agents against rapidly growing and starved Mycobacterium tuberculosis H37Rv. Few compounds have significant activity at attainable concentrations. However, two phenothiazine compounds at similar concentrations were bactericidal for starved and growing cells. These drugs appear to target a process important in both replicating and nonreplicating bacteria.