ABSTRACT Beet and lettuce are industrial vegetable crops valued for their high mineral, vitamin and fiber contents and for their additional health benefits. These crops are usually grown in intercrops in family production systems in a sustainable manner in semi-arid regions. This work aimed to evaluate the effects of incorporating different levels of hairy woodrose, as a green manure, on the agro-economic sustainability indicators of lettuce-beet intercrops, planted in different spatial arrangements and involving two successive croppings. The experimental design was a randomized complete blocks with treatments arranged in a 4 x 3 factorial scheme, corresponding to four hairy woodrose levels incorporated into the soil (6, 19, 32 and 45 t ha-1, dry basis) and three spatial arrangements between the component crops (2:2, 3:3 and 4:4), with four replications. The optimized agroeconomic performance of lettuce-beet intercropping was achieved with the incorporation of approximately 35.30 t ha-1 hairy woodrose. The lettuce crop contributed significantly to the productivity efficiency and sustainability of the intercropping with beet, compared to the single vegetable crops. The spatial arrangements between component crops did not affect the agroeconomic performance of the lettuce intercropped with beet.