Dissemin is shutting down on January 1st, 2025

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Frontiers Media, Frontiers in Neuroscience, (9), 2015

DOI: 10.3389/fnins.2015.00053

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Non-cell autonomous and non-catalytic activities of ATX in the developing brain

Journal article published in 2015 by Raanan Greenman, Anna Gorelik, Tamar Sapir, Jan Baumgart ORCID, Vanessa Zamor, Michal Segal-Salto, Smadar Levin-Zaidman, Vassilis Aidinis, Junken Aoki, Robert Nitsch, Johannes Vogt ORCID, Orly Reiner ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The intricate formation of the cerebral cortex requires a well-coordinated series of events, which are regulated at the level of cell-autonomous and non-cell autonomous mechanisms. Whereas cell-autonomous mechanisms that regulate cortical development are well-studied, the non-cell autonomous mechanisms remain poorly understood. A non-biased screen allowed us to identify Autotaxin (ATX) as a non-cell autonomous regulator of neural stem cells. ATX (also known as ENPP2) is best known to catalyze lysophosphatidic acid (LPA) production. Our results demonstrate that ATX affects the localization and adhesion of neuronal progenitors in a cell autonomous and non-cell autonomous manner, and strikingly, this activity is independent from its catalytic activity in producing LPA.