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American Society of Hematology, Blood, p. blood-2018-03-837468

DOI: 10.1182/blood-2018-03-837468

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Genetic and epigenetic evolution as a contributor to WT1-mutant leukemogenesis

Journal article published in 2018 by Elodie Pronier, Robert L. Bowman, Jihae Ahn, Jacob Glass, Cyriac Kandoth, Tiffany R. Merlinsky, Justin T. Whitfield, Benjamin H. Durham ORCID, Antoine Gruet, Amritha Varshini Hanasoge Somasundara ORCID, Raajit Rampal, Ari Melnick, Richard P. Koche, Barry S. Taylor, Ross L. Levine ORCID
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Distributing this paper is prohibited by the publisher

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Abstract

Key Points Wt1 heterozygous loss enhanced stem cell self-renewal in an age-dependent manner. Wt1-haploinsufficient leukemias require additional events to promote hematopoietic transformation.