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Public Library of Science, PLoS Genetics, 12(7), p. e1002403, 2011

DOI: 10.1371/journal.pgen.1002403

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The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

Journal article published in 2011 by Sandra Blanco, Agata Kurowski ORCID, Jennifer Nichols, Fiona M. Watt ORCID, Salvador Aznar Benitah, Michaela Frye
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Homeostasis of most adult tissues is maintained by balancing stem cell self-renewal and differentiation, but whether post-transcriptional mechanisms can regulate this process is unknown. Here, we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin. In the epidermis, this methyltransferase is found in a defined sub-population of hair follicle stem cells poised to undergo lineage commitment, and its depletion results in enhanced quiescence and aberrant stem cell differentiation. Our results reveal that post-transcriptional RNA methylation can play a previously unappreciated role in controlling stem cell fate.