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Public Library of Science, PLoS ONE, 4(10), p. e0124670, 2015

DOI: 10.1371/journal.pone.0124670

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Expression of Sirtuin 1 and 2 Is Associated with Poor Prognosis in Non-Small Cell Lung Cancer Patients

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) are NAD+-dependent protein deacetylases involved in the regulation of key cancer-associated genes. In this study we evaluated the relevance of these deacetylases in lung cancer biology.