Published in
American Society of Hematology, Blood, 10(130), p. 1213-1222
DOI: 10.1182/blood-2016-11-750976
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A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program
Journal article published in 2017 by
Shan Lin 
,
Anetta Ptasinska,
Xiaoting Chen,
Mahesh Shrestha,
Salam A. Assi,
Paulynn S. Chin,
Maria R. Imperato,
B. J. Aronow,
Jingsong Zhang,
Matthew T. Weirauch,
Constanze Bonifer ,
James C. Mulloy
,
Anetta Ptasinska,
Xiaoting Chen,
Mahesh Shrestha,
Salam A. Assi,
Paulynn S. Chin,
Maria R. Imperato,
B. J. Aronow,
Jingsong Zhang,
Matthew T. Weirauch,
Constanze Bonifer ,
James C. Mulloy
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Abstract
Key Points Increased FOXO1 is oncogenic in human CD34+ cells and promotes preleukemia transition. FOXO1 is required by AE preleukemia cells for the activation of a stem cell molecular program.