Published in
American Society of Hematology, Blood, 5(125), p. 784-792, 2015
DOI: 10.1182/blood-2014-07-592881
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- American Society of Hematology | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [www.researchgate.net]
- [www.ncbi.nlm.nih.gov] | PDF
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Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell–depleted stem cell transplantation
Journal article published in 2015 by
Nirali N. Shah,
Kristin Baird,
Cynthia P. Delbrook,
Thomas A. Fleisher,
Mark E. Kohler 
,
Shakuntala Rampertaap,
Kimberly Lemberg,
Carolyn K. Hurley,
David E. Kleiner,
Melinda S. Merchant,
Stefania Pittaluga,
Marianna Sabatino,
David F. Stroncek,
Alan S. Wayne,
Hua Zhang
and other authors.
,
Shakuntala Rampertaap,
Kimberly Lemberg,
Carolyn K. Hurley,
David E. Kleiner,
Melinda S. Merchant,
Stefania Pittaluga,
Marianna Sabatino,
David F. Stroncek,
Alan S. Wayne,
Hua Zhang
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Acute GVHD occurred in 5 of 9 patients after major histocompatibility–matched, T-cell–depleted peripheral blood stem cell transplantation plus IL-15/4-1BBL aNK-DLI. GVHD was more common in matched unrelated donor transplants and associated with higher CD3 chimerism, suggesting that aNK-DLI may augment T-cell alloreactivity.