Published in
American Society of Hematology, Blood, 16(130), p. 1845-1856
DOI: 10.1182/blood-2017-05-786004
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Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis
Journal article published in 2017 by
Edyta Glogowska,
Eve R. Schneider,
Yelena Maksimova,
Vincent P. Schulz,
Kimberly Lezon-Geyda,
John Wu,
Kottayam Radhakrishnan,
Siobán B. Keel,
Donald Mahoney,
Alison M. Freidmann,
Rachel A. Altura,
Elena O. Gracheva,
Sviatoslav N. Bagriantsev,
Theodosia A. Kalfa 
,
Patrick G. Gallagher
,
Patrick G. Gallagher
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Abstract
Key Points There is heterogeneity in the clinical, laboratory, and genetic bases of HX. Alterations in PIEZO1 channel kinetics, response to osmotic stress, and membrane trafficking may contribute to channel dysfunction in HX.