Published in
American Society of Hematology, Blood, 11(131), p. 1206-1218, 2018
DOI: 10.1182/blood-2017-05-786947
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Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia
Journal article published in 2018 by
Pavlina Janovska,
Jan Verner,
Jiri Kohoutek,
Lenka Bryjova,
Michaela Gregorova 
,
Marta Dzimkova,
Hana Skabrahova,
Tomasz Radaszkiewicz,
Zuzana Hoferova,
Petra Ovesna,
Katerina Vasickova,
Olga Vondalova Blanarova,
Lucie Smyckova,
Tereza Nemcova,
Alexander Egle
and other authors.
,
Marta Dzimkova,
Hana Skabrahova,
Tomasz Radaszkiewicz,
Zuzana Hoferova,
Petra Ovesna,
Katerina Vasickova,
Olga Vondalova Blanarova,
Lucie Smyckova,
Tereza Nemcova,
Alexander Egle
and other authors.
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Abstract
Key PointsCK1 inhibition significantly blocks microenvironmental interactions of CLL cells. CK1 inhibition slows down development of CLL-like disease in the Eμ-TCL1 mouse model.