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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 5(62), 2018

DOI: 10.1128/aac.00018-18

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Promoter Variation and Gene Expression of mcr-1 -Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital

Journal article published in 2018 by Bin Huang, Yuting He, Xingyan Ma, Renxin Cai, Jianming Zeng, Yang Lu, Weizheng Zhang, Kai Lan, Sunmei E., Yi-Wei Tang ORCID, Barry N. Kreiswirth, Cha Chen, Liang Chen ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

ABSTRACT Next-generation sequencing of 6 mcr-1 -harboring Escherichia coli and Klebsiella pneumoniae isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking the mcr-1 gene. While sequence variations significantly affected the expression and promoter activity of mcr-1 , the mcr-1 gene expression levels did not correlate with the in vitro colistin resistance levels, which warrants further in-depth investigations.