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American Association for the Advancement of Science, Science, 6384(360), p. 50-57, 2018

DOI: 10.1126/science.aao2300

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CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage

Journal article published in 2018 by Hiroki Abe ORCID, Susumu Jitsuki ORCID, Waki Nakajima ORCID, Yumi Murata ORCID, Aoi Jitsuki-Takahashi ORCID, Yuki Katsuno, Hirobumi Tada ORCID, Akane Sano ORCID, Kumiko Suyama ORCID, Nobuyuki Mochizuki ORCID, Takashi Komori ORCID, Hitoshi Masuyama ORCID, Tomohiro Okuda ORCID, Yoshio Goshima ORCID, Noriyuki Higo ORCID and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A small molecule for stroke therapy Better therapies for motor impairments after stroke are greatly needed. In mice and nonhuman primates, Abe et al. found that edonerpic maleate enhanced synaptic plasticity and functional recovery after a traumatic insult to the brain (see the Perspective by Rumpel). This recovery of motor function was accompanied by functional reorganization of the cortex. Science , this issue p. 50 ; see also p. 30