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Oxford University Press (OUP), Bioinformatics, 9(31), p. 1505-1507

DOI: 10.1093/bioinformatics/btu827

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diXa: a data infrastructure for chemical safety assessment

Journal article published in 2014 by Hendrickx Dm, Diana M. Hendrickx, Aerts Hj, Hugo J. W. L. Aerts, Ebbels Tm, Florian Caiment, Evelo Ct, Dominic Clark, Timothy M. D. Ebbels, Hans Gmuender, Chris T. Evelo ORCID, Dennie G. A. J. Hebels, Hebels Dg, Ralf Herwig, Jürgen Hescheler and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Motivation: The field of toxicogenomics (the application of ‘-omics’ technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available.