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Beilstein-Institut, Beilstein Journal of Organic Chemistry, (10), p. 1603-1612, 2014

DOI: 10.3762/bjoc.10.166

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Photoswitchable precision glycooligomers and their lectin binding

Journal article published in 2014 by Daniela Ponader, Sinaida Igde, Marko Wehle, Katharina Märker ORCID, Mark Santer, David Bléger, Laura Hartmann
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The synthesis of photoswitchable glycooligomers is presented by applying solid-phase polymer synthesis and functional building blocks. The obtained glycoligands are monodisperse and present azobenzene moieties as well as sugar ligands at defined positions within the oligomeric backbone and side chains, respectively. We show that the combination of molecular precision together with the photoswitchable properties of the azobenzene unit allows for the photosensitive control of glycoligand binding to protein receptors. These stimuli-sensitive glycoligands promote the understanding of multivalent binding and will be further developed as novel biosensors.