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Oxford University Press, Nucleic Acids Research, 12(40), p. 5262-5270, 2012

DOI: 10.1093/nar/gks158

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CTCF binds to sites in the major histocompatibility complex that are rapidly reconfigured in response to interferon-gamma

Journal article published in 2012 by Diego Ottaviani, Elliott Lever, Shihong Mao, Rossitza Christova, Babatunji W. Ogunkolade, Tania A. Jones, Jaroslaw Szary, Johan Aarum, Muhammad A. Mumin, Christopher A. Pieri, Stephen A. Krawetz, Denise Sheer ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Activation of the major histocompatibility complex (MHC) by interferon-gamma (IFN−γ) is a fundamental step in the adaptive immune response to pathogens. Here, we show that reorganization of chromatin loop domains in the MHC is evident within the first 30 min of IFN−γ treatment of fibroblasts, and that further dynamic alterations occur up to 6 h. These very rapid changes occur at genomic sites which are occupied by CTCF and are close to IFN−γ-inducible MHC genes. Early responses to IFN−γ are thus initiated independently of CIITA, the master regulator of MHC class II genes and prepare the MHC for subsequent induction of transcription.