Published in
American Society of Hematology, Blood, p. blood-2018-02-833582
DOI: 10.1182/blood-2018-02-833582
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CD44 is a RAS/STAT5-regulated invasion receptor that triggers disease expansion in advanced mastocytosis
Journal article published in 2018 by
Niklas Mueller 
,
Daniel Wicklein,
Gregor Eisenwort,
Mohamad Jawhar,
Daniela Berger,
Gabriele Stefanzl ,
Georg Greiner,
Alexandra Boehm,
Christoph Kornauth,
Leonhard Muellauer,
Susanne Sehner,
Gregor Hoermann,
Wolfgang R. Sperr,
Philipp B. Staber,
Ulrich Jaeger
and other authors.
,
Daniel Wicklein,
Gregor Eisenwort,
Mohamad Jawhar,
Daniela Berger,
Gabriele Stefanzl ,
Georg Greiner,
Alexandra Boehm,
Christoph Kornauth,
Leonhard Muellauer,
Susanne Sehner,
Gregor Hoermann,
Wolfgang R. Sperr,
Philipp B. Staber,
Ulrich Jaeger
and other authors.
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Abstract
Key Points CD44 is a RAS/STAT5-dependent target in neoplastic mast cells and correlates with aggressiveness of mastocytosis. Depletion of CD44 in neoplastic mast cells is associated with reduced invasion and prolonged survival in SCID mice.