Published in
American Association for the Advancement of Science, Science Signaling, 539(11), 2018
DOI: 10.1126/scisignal.aas9609
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Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization
Journal article published in 2018 by
Elke Miess 
,
Arisbel B. Gondin,
Arsalan Yousuf ,
Ralph Steinborn ,
Nadja Mösslein ,
Yunshi Yang ,
Martin Göldner,
Julia G. Ruland,
Moritz Bünemann,
Cornelius Krasel ,
MacDonald J. Christie ,
Michelle L. Halls ,
Stefan Schulz ,
Meritxell Canals
,
Arisbel B. Gondin,
Arsalan Yousuf ,
Ralph Steinborn ,
Nadja Mösslein ,
Yunshi Yang ,
Martin Göldner,
Julia G. Ruland,
Moritz Bünemann,
Cornelius Krasel ,
MacDonald J. Christie ,
Michelle L. Halls ,
Stefan Schulz ,
Meritxell Canals
This paper is made freely available by the publisher.
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Abstract
High-efficacy opioids enhance receptor desensitization due to rapid and sustained GRK2/β-arrestin interactions.