Published in
American Society of Hematology, Blood, 18(131), p. 2074-2085
DOI: 10.1182/blood-2017-06-792614
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Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease
Journal article published in 2018 by
Shuichiro Takahashi 
,
Daigo Hashimoto ,
Eiko Hayase,
Reiki Ogasawara,
Hiroyuki Ohigashi,
Takahide Ara,
Emi Yokoyama,
Ko Ebata,
Satomi Matsuoka,
Geoffrey R. Hill ,
Junichi Sugita,
Masahiro Onozawa,
Takanori Teshima
,
Daigo Hashimoto ,
Eiko Hayase,
Reiki Ogasawara,
Hiroyuki Ohigashi,
Takahide Ara,
Emi Yokoyama,
Ko Ebata,
Satomi Matsuoka,
Geoffrey R. Hill ,
Junichi Sugita,
Masahiro Onozawa,
Takanori Teshima
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Abstract
Key Points Skin GVHD targets Lgr5+ HFSCs in association with impaired hair regeneration and wound healing. Topical ruxolitinib, unlike corticosteroids, protects Lgr5+ skin stem cells and maintains skin homeostasis in skin GVHD.