Published in
American Society of Hematology, Blood, 5(130), p. 643-654
DOI: 10.1182/blood-2017-03-769315
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Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor
Journal article published in 2017 by
Vera Münch,
Geertruy te Kronnie,
Julia Herzig,
Salih Demir,
Felix Seyfried,
Johann M. Kraus,
Hans A. Kestler,
Luca Trentin 
,
Rolf Köhler,
Thomas F. E. Barth,
G. Te Kronnie,
Klaus-Michael Debatin,
Lüder H. Meyer
,
Rolf Köhler,
Thomas F. E. Barth,
G. Te Kronnie,
Klaus-Michael Debatin,
Lüder H. Meyer
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Abstract
Key Points Xenografted ALL cells faithfully recapitulate CNS leukemia and are characterized by high expression of VEGF, mediating CNS entry of ALL cells. VEGF captured by bevacizumab in vivo specifically reduces CNS leukemia, providing a novel strategy to target CNS involvement in ALL.