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American Society of Hematology, Blood, p. blood-2018-02-831065

DOI: 10.1182/blood-2018-02-831065

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Aged murine hematopoietic stem cells drive aging-associated immune remodeling

Journal article published in 2018 by Hanna Leins, Medhanie Mulaw, Karina Eiwen, Vadim Sakk, Ying Liang, Michael Denkinger ORCID, Hartmut Geiger, Reinhold Schirmbeck
This paper was not found in any repository; the policy of its publisher is unknown or unclear.
This paper was not found in any repository; the policy of its publisher is unknown or unclear.

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Abstract

Key Points Phenotypic and functional changes in T and B cells of old mice are primarily driven by aging of HSCs. CASIN-treated aged HSCs reconstitute an immune system with a function similar to that in young animals.