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American Association for the Advancement of Science, Science Advances, 10(3), 2017

DOI: 10.1126/sciadv.1701383

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Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The unspliced form of XBP1 stabilizes MDM2 protein by inhibiting its ubiquitination and regulates the MDM2/p53 axis.