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American Academy of Sleep Medicine, Journal of Clinical Sleep Medicine

DOI: 10.5664/jcsm.1480

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Sodium Oxybate and Sleep Apnea: A Clinical Case

Journal article published in 2011 by Sarah Hartley ORCID, Maria-Antonia Quera-Salva, Mourad Machou
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Sodium oxybate (GHB, Xyrem, Jazz Pharmaceuticals) is used to treat cataplexy in patients with narcolepsy. We report the case of a middle aged, normo-ponderal narcoleptic woman without risk factors who developed reversible sleep apnea and objective sleepiness when treated by sodium oxybate, with an apnea-hypopnea index (AHI) of 19.7 on sodium oxybate and AHI 4.8 without treatment. Despite a subjective improvement in vigilance, mean sleep latency on MWT decreased from 21 minutes to 8 minutes on sodium oxybate.