Published in
American Society of Hematology, Blood, 2(132), p. 197-209
DOI: 10.1182/blood-2017-11-816355
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Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion
Journal article published in 2018 by
Irina Pleines 
,
Marion Lebois,
Pradnya Gangatirkar,
Amanda E. Au,
Rachael M. Lane,
Katya J. Henley,
Maria Kauppi,
Jason Corbin,
Ping Cannon,
Jonathan Bernardini ,
Imala Alwis ,
Kate E. Jarman,
Sarah Ellis,
Donald Metcalf,
Shaun P. Jackson
and other authors.
,
Marion Lebois,
Pradnya Gangatirkar,
Amanda E. Au,
Rachael M. Lane,
Katya J. Henley,
Maria Kauppi,
Jason Corbin,
Ping Cannon,
Jonathan Bernardini ,
Imala Alwis ,
Kate E. Jarman,
Sarah Ellis,
Donald Metcalf,
Shaun P. Jackson
and other authors.
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Abstract
Key Points BAK/BAX depletion in murine platelets reveals that intrinsic apoptosis is not required for the development of the platelet storage lesion. Restriction of platelet life span by intrinsic apoptosis is pivotal to maintain a functional, hemostatically reactive platelet population.